Subject(s)
Adult , Female , Humans , Male , Middle Aged , Scleroderma, Localized/complications , Scleroderma, Localized/epidemiology , Thyroid Diseases/diagnosis , Thyroid Diseases/enzymology , Thyroid Diseases/epidemiology , Thyroid Diseases/etiology , Thyroid Diseases/diagnostic imaging , Thyroid Gland/analysis , Thyroid Gland/enzymology , Thyroid Gland/diagnostic imaging , Thyroid Hormones/analysis , Young AdultABSTRACT
Se analizan 850 biopsias tiroideas por punción con aguja Tru-cut, producto de mi experiencia personal desde 1973-91 (18 años), realizadas en los Hospitales Universitario y F.A. Rísquez de Caracas y en la Clínica Luis Razetti. Predominó el sexo femenino con 820 (96%) y 30 (4%) hombres, en edades comprendidas entre los 10 y 75 años. La correlación entre biopsia por punción con Tru-cut y la biopsia de la pieza quirúrgica en 364 operados fue la siguiente: 45 pacientes con Graves-Basedow se operaron y 42 correspondieron (93%) y 3 (7%) fueron tiroiditis linfocitarias; 20 pacientes con bocios coloides se operaron 20 y 15 (75%) correspondieron, y 5 (25%) fueron bocios adenomatosos: 140 casos con bocios adenomatosos se operaron 130 pacientes correspondieron (93%), 5 (3%) fueron carcinoma y 5 (3%), tiroiditis crónicas; de 150 nódulos operados 116 (77%) correspondieron (77%) como adenomas y quistes, 20 casos (13%) fueron bocios adenomatosos y 14 (9%) carcinomas. De los 9 carcinomas operados se correspondieron todos por ser lesiones avanzadas. Hubo un total de 28 carcinomas (8%) de todos los operados. La biopsia se hace ambulatoria con complicaciones mínimas, con un 94% de muestras adecuadas y 6% de muestras inadecuadas
Subject(s)
Child , Adolescent , Adult , Middle Aged , Male , Female , Biopsy, Needle/statistics & numerical data , Thyroid Gland/analysis , Biopsy, Needle/methodsABSTRACT
Plasma lipids of 24 euthyroid subjects with thyroid adenoma and non-toxic primary differentiated thyroid carcinoma (papillary and follicular types) were assessed and compared with a similar investigation conducted on 20 normal subjects. A parallel study with thyroid tumor tissues examined the lipid changes which occurred in the same group of patients. These were compared with the picture seen in 5 normal thyroids. The investigations examined the changes in total lipids; total, free and esterified cholesterol; total phospholipids; lecithin; cephalin and sphingomyelin; triglycerides and free fatty acids in both serum and thyroid tissue. Compared with normal subjects, the serum lipids were almost identical except for the concentration of free fatty acids which showed significantly lower values in the group with neoplastic changes. Tissue analysis of the cancerous thyroid however revealed a marked rise in virtually all lipid fractions but the cholesterol seemed to dominate the picture. The differential studies of total phospholipids for thyroid tissue membrane lipids further revealed a significant increase in the lecithin and sphingomyelin components of total phospholipids as well as the esterified cholesterol fraction in thyroid carcinoma. The changes in thyrophospholipids were more marked in females normal thyroids than males. An attempt has been made through evaluation of the results derived from differential lipid studies to elucidate the role of some of the various fractions determined and the possible effect of the changes described on thyroid hormone metabolism.